Num mundo onde a informação está disponível na ponta de um dedo, curiosamente, na grande maioria das vezes é preciso dedicar muito tempo na pesquisa daquilo que precisamos. O Dr. Ryan Lowery criou uma base de dados credível, um conjunto de publicações e artigos com informações importantes sobre a ciência das cetonas exógenas.
Alzheimer
- 2000: d-β-Hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease
- 2004: Effects of beta-hydroxybutyrate on cognition in memory-impaired adults.
- 2008: Ketone bodies as a therapeutic for Alzheimer’s disease
- 2016: Ketones block amyloid entry and improve cognition in an Alzheimer’s model
- 2019: Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease)
- 2020: A Dietary Ketone Ester Normalizes Abnormal Behavior in a Mouse Model of Alzheimer’s Disease
- 2020:β-hydroxybutyrate Impedes the Progression of Alzheimer’s Disease and Atherosclerosis in ApoE- Deficient Mice
Esclerose Lateral Amiotrófica (ELA) / Doença de Lou Gehrig’s
- 2013: High-Fat and Ketogenic Diets in Amyotrophic Lateral Sclerosis – Sabrina Paganoni, Anne-Marie Wills, 2013
- 2015: Nutritional/Metabolic Therapies in Animal Models of Amyotrophic Lateral Sclerosis, Alzheimer’s Disease, and Seizures
- 2017: Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments
Síndrome de Angelman
Ansiedade
- 2017:Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats
- 2018: Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats
- 2018:Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
Dédice de Atenção (ADHD)
- 2017: The Current Status of the Ketogenic Diet in Psychiatry
- 2019: Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature
Autismo
- 2016: Metabolism-Based Treatments for Autism Spectrum Disorder and Co-Morbidities
- 2017: Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches
- 2017: The Current Status of the Ketogenic Diet in Psychiatry
- 2017: Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?
- 2018: ketogenic diet as possible therapy of autism spectrum disorder — review and implication
Doença Bipolar
- 2019: Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature
- 2019: Ketosis and bipolar disorder: controlled analytic study of online reports | BJPsych Open
Cancro
- 2014: Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer
- 2015: Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice
- 2016: Metabolic effects of exogenous ketone supplementation – an alternative or adjuvant to the ketogenic diet as a cancer therapy?
- 2019: Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma
- 2019: HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma
CNS Toxicity
- 2013: Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats
Doença de Crohn’s
Depressão
Diabetes Tipo 2(Diabetes Mellitus)
- 2016: Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats
- 2016: Diabetic ketosis during hyperglycemic crisis is associated with decreased all-cause mortality in patients with type 2 diabetes mellitus
- 2018: Exogenous ketones lower blood glucose level
- 2018: The glucose‐lowering effects of exogenous ketones: is there therapeutic potential?
- 2019: Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models
- 2020: Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes in: European Journal of Endocrinology Volume 182 Issue 2 (2020)
Síndrome de Dravet
Epilepsia / Convulsões
- 1999: Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet
- 2000: The Ketogenic Diet: Seizure Control Correlates Better With Serum β-Hydroxybutyrate Than With Urine Ketones
- 2004: More fat and fewer seizures: dietary therapies for epilepsy
- 2012: Ketone bodies in epilepsy
- 2015: Ketone bodies mediate antiseizure effects through mitochondrial permeability transition
- 2017: Adenosine A1 Receptor Antagonism Abolished the Anti-seizure Effects of Exogenous Ketone Supplementation in Wistar Albino Glaxo Rijswijk Rats
- 2019:Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives
- 2019: Exogenous Ketone Supplementation Decreased the Lipopolysaccharide-Induced Increase in Absence Epileptic Activity in Wistar Albino Glaxo Rijswijk Rats
Performance
Gripe (Influenza)
GERD/Refluxo/Úlcera Esofágica
- 2006: A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms.
- 2016: Dietary carbohydrate intake, insulin resistance and gastro‐oesophageal reflux disease: a pilot study in European‐ and African‐American obese women
Deficiência GLUT1
- 2017: Individualizing Treatment Approaches for Epileptic Patients with Glucose Transporter Type1 (GLUT-1) Deficiency
- 2018: Exogenous ketones lower blood glucose level
- 2019: Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models
Doenças do armazenamento do glicogénio (GSD)
- 2005: Treatment of glycogenosis type V with ketogenic diet
- 2011: Successful Treatment of Severe Cardiomyopathy in Glycogen Storage Disease Type III With D,L-3-Hydroxybutyrate, Ketogenic and High-Protein Diet
- 2015: Ketogenic diets in patients with inherited metabolic disorders
Dislipidemia (Colesterol)
Doenças Inflamatórias
- 2015: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
- 2017: The promising potential role of ketones in inflammatory dermatologic disease: a new frontier in treatment research
- 2017: The effects of exogenous ketones on biomarkers of Crohn’s Disease
- 2017: Characterizing the metabolic effects of exogenous ketone supplementation – an alternative or adjuvant to the ketogenic diet
- 2018: Potential Synergies of β-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health
Linfedema
Défice múltiplo das desidrogenases dos ácidos gordos (MADD)
- 2014: Highly efficient ketone body treatment in multiple acyl-CoA dehydrogenase deficiency–related leukodystrophy2019: Long-term ketone body therapy of severe multiple acyl-CoA dehydrogenase deficiency: A case report
Enxaquecas
- 2014: Migraine improvement during short lasting ketogenesis: a proof‐of‐concept study
- 2019: Efficacy and safety of exogenous ketone bodies for preventive treatment of migraine: A study protocol for a single-centred, randomised, placebo-controlled, double-blind crossover trial
- 2019: Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention
Esclerose Múltipla (MS)
- 2012: Inflammation-Mediated Memory Dysfunction and Effects of a Ketogenic Diet in a Murine Model of Multiple Sclerosis2020: Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled study
Obesidade
Dores / Dores Crónicas
Doença de Parkinson
- 1999: d-β-Hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease
- 2018: Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats
- 2019: Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease)
Doença Renal
Síndrome do Ovário Policístico (PCOS)
- 2005: The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: A pilot study
- 2020: Effects of a ketogenic diet in overweight women with polycystic ovary syndrome
Doença do Stress Pós-Traumático
- 2018: Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats2019: Nuclear magnetic resonance spectroscopy based urinary metabolic profiling in post traumatic stress disorder rats2019: Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current
Síndroma de Rett
Sarcopenia
Esquizofrenia
- 2018: Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats
- 2018: The effects of the ketogenic diet on psychiatric symptomatology, weight and metabolic dysfunction in schizophrenia patients
- 2019: Ketogenic diet prevents impaired prepulse inhibition of startle in an acute NMDA receptor hypofunction model of schizophrenia
- 2019: Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature
- 2019: Ketogenic diet for schizophrenia: clinical implication : Current Opinion in Psychiatry
Enfarte
Traumatismo Craniano
- 2004: Increased cerebral uptake and oxidation of exogenous βHB improves ATP following traumatic brain injury in adult rats
- 2005: Age‐dependent reduction of cortical contusion volume by ketones after traumatic brain injury
- 2007: Cerebral Metabolic Adaptation and Ketone Metabolism after Brain Injury – Mayumi L Prins, 2008
- 2008: Fasting is neuroprotective following traumatic brain injury
- 2011: Clinical review: Ketones and brain injury | Critical Care | Full Text
- 2018: Modulation of cerebral ketone metabolism following traumatic brain injury in humans
